DISASTER MEDICINE No. 3 •2026

doi: 10.33266/2070-1004-2026-3

Original article

The Use of Xenogenic Wound Coverings and Amniotic Membrane in the Treatment of Victims with Combined Thermomechanical Injuries

Umnikov A.S. ¹, Udalov Yu.D.¹, Samoylov A.S. ², Astrelina T.A. ¹, Kobzeva I.V. ¹, Grechukhin D.A. ¹, Kopylov A.M. ¹

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¹ State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russian Federation

² Research Institute of Occupational Medicine named after acad. N.F.Izmerov, Moscow, Russian Federation

UDC 616-001.17-089.843:617-089.844

P. 74-79

 

Summary. The aim of the study – to comparatively evaluate the effectiveness of using amniotic membrane (AM) and xenogenic skin (XS) in the treatment of extensive thermal components of combined thermomechanical injuries.

Materials and methods of the study. The study included 33 patients with combined thermomechanical injuries. Patients were divided into 3 groups: the first group (n=11) received xenoderm treatment, the second group (n=9) underwent autodermoplasty treatment, and the third group (n=13) received combined treatment.

Statistical analysis was performed using the Friedman test and Spearman correlation analysis.

Results of the study. The median time of epithelization was: in the first group — 24 days [22–29], in the second group — 21 days [18–24], in the third group — 18 days [16–21]. Statistically significant differences between groups were found in terms of epithelization time (p=0.0004). The best results were obtained in the combined treatment group. The complication rate was: in the first group — 27.3%, in the second group — 22.2%, in the third group — 7.7%.

Conclusion. The combined treatment method showed statistically significant superiority over xenogenic skin application (p=0.0006). A strong positive correlation was found between burn area and epithelization time (r=0.682; p<0.001). The results confirm the effectiveness of the combined treatment method for thermal components in combined thermomechanical injuries.

Key words: amniotic membrane, biomedical technologies, burns, burn wound repair, combined thermomechanical injuries, victims, xenogenic wound coverings

For citation: Umnikov A.S., Udalov Yu.D., Samoylov A.S., Astrelina T.A., Kobzeva I.V., Grechukhin D.A., Kopylov A.M. The Use of Xenogenic Wound Coverings and Amniotic Membrane in the Treatment of Victims with Combined Thermomechanical Injuries. Meditsina Katastrof = Disaster Medicine. 2026;3:74-79 (In Russ.). Doi:10.33266/2070-1004-2026-3-74-79

 

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The material was received 19.02.26; the article after peer review procedure 06.07.26; the Editorial Board accepted the article for publication 16.09.26