DISASTER MEDICINE No. 3 •2026

doi: 10.33266/2070-1004-2026-3

Original article

Evaluation of the Effectiveness of the Local Hemostatic Agent for First Aid “Gemovis” (Hemostatic Gel) and its Effect on the Wall of the Wound Channel in the Experiment

Smorkalov A.Y. 1, Loginov V.I. 1, Rudnev S.A. 2, Rudneva T.S. 3, Nikol’skiy V.O. 4

Download the article in pdf format

1 Nizhny Novgorod Regional Blood Center named after N.Y.Klimova, Nizhny Novgorod, Russian Federation

2 Transmedtech Research and Production Company LLC, Lyubertsy, Russian Federation

3 Peoples Friendship University of Russia named after Patrice Lumumba Medical Institute, Moscow, Russian Federation

4 Nizhny Novgorod Regional Clinical Center of Phthisiopulmonology, Nizhny Novgorod, Russian Federation

UDC 616.71-003.93:576.385

P. 116-123

 

Summary. The purpose of the study. The present study was conducted to evaluate the effectiveness of the local hemostatic first aid agent “Gemovis” (Hemostatic Gel) and its effect on the wound canal wall in an experiment.

Materials and methods of research. Experimental studies were conducted on white mongrel male pigs weighing (51±5.3) kg. In total, 2 animals were involved in the experiment – 8 series (4 wounds in each animal). The wounds were sequentially inflicted and hemostatic agents were used in them, first on the left thigh and left shoulder, then after infusion therapy and hemodilution of the right thigh and right shoulder with damage to the main arteries. The effectiveness of the hemostatic drug was assessed by achieving primary temporary, secondary temporary and completed temporary hemostasis. The safety of the drug was assessed by microscopy of the wound canal wall with adjacent muscle tissues to a depth of 1 cm.

The results of the study and their analysis. The study revealed that the technique widely used to evaluate the effectiveness of traditional local hemostatic agents, presented in the form of bandages or granules, is not sufficiently adapted to studies of the characteristics of gel-like analogues. At the same time, applying the volume of MGS “Gemovis” to the area of a stab wound with damage to the main artery showed its high effectiveness. The use of the gel-like volume of MGS “Gemovis” in conditions of narrow wound channels with damage to the main vessels, in the absence of the possibility of using traditional local hemostatic agents followed by tamponing, made it possible to achieve primary, secondary and complete hemostasis without the use of tamponade and pressure bandage. The histological studies of the wound canal wall showed the absence of deep changes in the tissues. That in case of gunshot and shrapnel wounds will not affect the course of the wound process. 

Keywords: bleeding, effectiveness, first aid, local hemostatic agent Hemovis, prehospital stage, wound canal wall

For citation: Smorkalov A.Y., Loginov V.I., Rudnev S.A., Rudneva T.S., Nikol’skiy V.O. Evaluation of the Effectiveness of the Local Hemostatic Agent for First Aid “Gemovis” (Hemostatic Gel) and its Effect on the Wall of the Wound Channel in the Experiment. Meditsina Katastrof = Disaster Medicine. 2026;3:116-123 (In Russ.). Doi:10.33266/2070-1004-2026-3-116-123

 

СПИСОК ИСТОЧНИКОВ / REFERENCES

  1. Eastridge B.J., Mabry R.L., Seguin P., et al. Death on the Battlefield (2001-2011): Implications for the Future of Combat Casualty Care. J. Trauma Acute Care Surg. 2012;73;6 suppl.5:S431-437.
  2. Winstanley M., Smith J.E., Wright C. Catastrophic Haemorrhage in Military Major Trauma Patients: a Retrospective Data Base Analysis of Haemostatic Agents Use Don the Battlefield. Journal of the Royal Army Medical Corps. 2019;165;6:405-409.
  3. Vrancken S.M., Borger van der Burg B.L.S., DuBose J.J., et al. Advanced Bleeding Control in Combat Casualty Care: an International, Expert-Based Delphi Consensus. J Trauma Acute Care Surg. 2022;93:256-264.
  4. Beaman H.T., Shepherd E., Satalin J., et al. Hemostatic Shape Memory Polymer Foams with Improved Survival in a Lethal Traumatic Hemorrhage Model. Acta Biomater. 2022;137:112-123.
  5. Xia Q., Huang J., Feng Q., et al. Size and Celltype-Dependent Cellular Uptake, Cytotoxicity and in Vivo Distribution of Gold Nanoparticles. Int J Nanomedicine. 2019;14:6957-6970.
  6. Kheirabadi B.S., Arnaud F., McCarron R., et al. Development of a Standards Wine Hemorrhage Model for Efficacy Assessment of Topical hemostatic Agents. Journal of Trauma. 2011;71;1:139-146.
  7. Самохвалов И.М., Рева В.А., Денисов А.В., Головко К.П., Сохранов М.В., Телицкий С.Ю., Юдин А.Б. Усовершенствование экспериментальной модели для изучения эффективности местных гемостатических средств // Военно-медицинский журнал. 2015. Т. 36. №3. С. 19-25 [Samokhvalov I.M., Reva V.A., Denisov A.V., Golovko K.P., Sokhranov M.V., Telitskiy S.Yu., Yudin A.B. Improvement of the Experimental Model for Studying the Effectiveness of Local Hemostatic Agents. Voyenno-Meditsinskiy Zhurnal = Military Medical Journal. 2015;336;3:19-25 (In Russ.)].
  8. Edwards J., Abdou H., Patel N., et al. The Functional Vascular Anatomy of the Swine for Research. Vascular. 2022;30;2:392-402.
  9. Логинов В.И., Сморкалов А.Ю., Никольский В.О. и др. Гистологическая оценка воздействия местных гемостатических средств на стенку раневого канала при ранениях мягких тканей в эксперименте // Современные проблемы науки и образования. 2022. №6-1. С. 110 [Loginov V.I., Smorkalov A.Yu., Nikol’skiy V.O., et al. Histological Assessment of the Effect of Local Hemostatic Agents on the Wound Channel Wall in Soft Tissue Injuries in an Experiment. Sovremennyye Problemy Nauki i Obrazovaniya = Modern Problems of Science and Education. 2022;6-1:110 (In Russ.)]. Doi: 10.17513/spno.32185. URL: https://science-education.ru/ru/article/view?id=32185 (Date of Access: 01.03.2026).
  10. China A., Lipsky A.M., Nadler R., et al. Prehospital Use of Hemostatic Dressings by the Israel Defense Forces Medical Corps: a Case Series of 122 Patients. J. Trauma Acute Care Sarg. 2015;79;4:2:204-209.
  11. Kimberly A.G., Alexander J.K., Alexis L.L, et al Evaluation of Novel Hemostatic Agents in a Coagulopathic Swine Model of Junctional Hemorrhage. J Trauma Acute Care Surg. 2023;1;95:144-151.
  12. Edwards J.V., Prevost N.T., Hinchliffe D.J., et al. Preparation and Activity of Hemostatic and Anti-bacterial Dressings with Greige Cotton / Zeolite Formularies Having Silver and Ascorbic Acid Finishes. Int J Mol Sci. 2023;24;23:17115. Doi: 10.3390/ijms242317115.PMID: 38069435.

 

The material was received 27.03.26; the article after peer review procedure 07.07.26; the Editorial Board accepted the article for publication 16.09.26
Copyright © 2026 “Disaster Medicine” Journal | Powered by “Disaster Medicine” Journal