DISASTER MEDICINE No. 4•2023

https://doi.org/10.33266/2070-1004-2023-4

Original article

Emergency Superdeep Hypothermia in Circulatory Arrest Caused by Massive Blood Loss: from the Experience of Tactical and Special Exercises

Reva V.A. 1,2, Goncharov S.F. 3,4, Potemkin V.D. 1, Baranov M.I. 1, Vertiy A.B. 1, Sazhneva M.Y.1, Samakaeva A.R. 5,
Shelukhin D.A. 6

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1 Kirov Military Medical Academy of the Ministry of Defense of Russia, St. Petersburg, Russian Federation

2 Russian Biotechnological University, Moscow, Russian Federation

3 State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russian Federation

4 Russian Medical Academy of Continuous Professional Education, the Ministry of Health of the Russian Federation, Moscow, Russian Federation

5 Nizhnevartovsk District Clinical Hospital, Nizhnevartovsk, Russian Federation

6 Group Company «MMC», St. Petersburg, Russian Federation

UDC 616-005.4+614.88

Pp. 57-64

Summary. The aim of the study is to evaluate the possibility of using the technology of emergency superdeep hypothermia (ESH), which consists in rapid cooling of vital organs (up to 10 °C) and the whole body (up to 20 °C), in the conditions of simulation of stage treatment of the wounded with traumatic cardiac arrest (TCA) during the annual tactical-special military-medical exercise “Ochag” in the training center of the Military Medical Academy named after S.M. Kirov.

Materials and research methods. A mobile resuscitation and surgical team consisting of two surgeons, one anesthesiologist-surgeon, an anesthesia nurse, and an operating room nurse was formed for the study, which was placed in a reinforced concrete bunker located slightly away from the main evacuation routes for the wounded (simulants). The personnel of the team, represented by the staff of the Special Medical Unit (SMU) of the Military Medical Academy, was reinforced by a surgeon trained in the use of extracorporeal membrane oxygenation and experienced in the use of this technology in the clinic in order to practice new technologies. The main tasks of the team included: primary surgical care of seriously wounded patients in case of a small incoming flow and primary medical and sanitary care in case of mass admission of the wounded.

Results of the study and their analysis. The results of the study showed the potential possibility — primarily from the point of view of logistics and organization — of medical evacuation of a casualty in the state of ESH between the deployed stages of medical care. In the course of the experiment it was established that the duration of medical evacuation in hypothermic circulatory arrest should be less than 120 min. It is concluded that it is necessary to carry out additional research to determine the optimal parameters of the application of the ESG technique for the rescue of victims with TCA.

Keywords: circulatory arrest, emergency hypothermia, extracorporeal membrane oxygenation, hibernation, massive blood loss, Military Medical Academy named after S.M.Kirov, tactical and special military-medical exercises, traumatic cardiac arrest

Conflict of interest. The authors declare no conflict of interest

For citation: Reva V.A., Goncharov S.F., Potemkin V.D., Baranov M.I., Vertiy A.B., Sazhneva M.Y., Samakaeva A.R., Shelukhin D.A. Emergency Superdeep Hypothermia in Circulatory Arrest Caused by Massive Blood Loss: from the Experience of Tactical and Special Exercises. Meditsina Katastrof = Disaster Medicine. 2023;4:57-64 (In Russ.). https://doi.org/10.33266/2070-1004-2023-4-57-64

 

СПИСОК ИСТОЧНИКОВ / REFERENCES

  1. Lott C., Truhlář A., Alfonzo A., Barelli A., González-Salvado V., Hinkelbein J., et al. European Resuscitation Council Guidelines 2021: Cardiac Arrest in Special Circumstances. Resuscitation. 2021:1:152–219.
  2. Crewdson K., Lockey D. Mortality in Traumatic Cardiac Arrest. Resuscitation. 2017; 1:113-121.
  3. Teeter W., Haase D. Updates in Traumatic Cardiac Arrest. Emerg. Med. Clin. North Am. 2020;38;4:891–901.
  4. Vianen N.J., Van Lieshout E.M.M., Maissan I.M., et al. Prehospital Traumatic Cardiac Arrest: a Systematic Review and Meta-Analysis. Eur. J. Trauma Emerg. Surg. 2022;48;4:3357-3372.
  5. Granholm F., Tin D., Ciottone G.R. Mass Casualty CPR: Flawed, Futile or a First Responder Mandate? Resuscitation. 2022;181:132.
  6. Madurska M.J., Ross J.D., Scalea T.M., Morrison J.J. State-of-the-Art Review — Endovascular Resuscitation. Shock. 2021;55;3:288–300.
  7. Soar J., Berg K.M., Andersen L.W., et al. Adult Advanced Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Resuscitation. 2020;156:80–119.
  8. Macku D., Hedvicak P., Quinn J., Bencko V. Prehospital Medicine and the Future Will ECMO Ever Play a Role?. J. Spec. Oper. Med. 2018;18;1:133–138.
  9. Reva V.A., Pochtarnik A.A., Shelukhin D.A. et al. Battlefield Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest: A Feasibility Study During Military Exercises. J. Spec. Oper. Med. 2020;20;4:77–83.
  10. Неговский В.А. Соболева В.И., Гурвич Н.Л., Киселева К.С. Восстановление жизненных функций организма после 2 часов клинической смерти в условиях глубокой гипотермии (предварительное сообщение) // Вестн. Акад. мед. наук СССР. 1960. № 10. С. 40–44. [Negovskiy V.A. Soboleva V.I., Gurvich N.L., Kiseleva K.S. Recovery of Vital Functions of the Body after 2 Hours of Clinical Death Under Conditions of Deep Hypothermia (Preliminary Report). Bull. Acad. Medical. Sciences of the USSR. 1960;10:40-44 (In Russ)].
  11. Bellamy R., Safar P., Tisherman S.A., et al. Suspended Animation for Delayed Resuscitation. Crit. Care Med. 1996;24;2:24-47.
  12. Tisherman S.A., Alam H.B., Rhee P.M. et al. Development of the Emergency Preservation and Resuscitation for Cardiac Arrest from Trauma Clinical Trial. J. Trauma Acute Care Surg. 2017;83:803–809.
  13. Рева В.А., Гончаров С.Ф., Потемкин В.Д. и др. Применение саморасширяющейся полиуретановой пены для остановки продолжающегося внутрибрюшного кровотечения в условиях военных конфликтов и чрезвычайных ситуаций: из опыта проведения тактико-специальных учений // Медицина катастроф. 2023. № 1. С. 77–82. [Reva V.A., Goncharov S.F., Potemkin V.D., Baranov M.I., Zhabin A.V., Chepur S.V. Usage of Self-Expanding Polyurethane Foam for Resolving of Ongoing Intra-Abdominal Hemorrhaging in Conditions of Military Conflict and Emergency Situations Basing on an Experience of Tactical-Special Exercises. Meditsina Katastrof = Disaster Medicine. 2023;1:77-82 (In Russ.). https://doi.org/10.33266/2070-1004-2023-1-77-82].
  14. Покровский В.М. В России заморозили мозг человека. Наука. 2003. URL: https://www.ng.ru/science/2003-12-10/15_brain.html (дата обращения: 01.10.2023). [Pokrovskiy V.М. In Russia the Human Brain Was Frozen. Nauka Publ., 2003 (In Russ.)].
  15. Tisherman S.A., Safar P., Radovsky A., et al. Therapeutic Deep Hypothermic Circulatory Arrest in Dogs: a Resuscitation Modality for Hemorrhagic Shock with «Irreparable» Injury. J Trauma. 1990;30;7:836–847.
  16. Capone A., Safar P., Radovsky A., et al. Complete Recovery after Normothermic Hemorrhagic Shock and Profound Hypothermic Circulatory Arrest of 60 minutes in Dogs. J Trauma. 1996;40;3:388–395.
  17. Tisherman S.A., Safar P., Radovsky A., et al. Profound Hypothermia (less than 10 degrees C) Compared with Deep Hypothermia (15 degrees C) Improves Neurologic Outcome in Dogs after Two Hours’ Circulatory Arrest Induced to Enable Resuscitative Surgery. J Trauma. 1991;31;8:1051–1062.
  18. Liu Y., Li S., Li Z., et al. A safety Evaluation of Profound Hypothermia-Induced Suspended Animation for Delayed Resuscitation at 90 or 120 min. Mil. Med. Res. 2017;4:1-16.
  19. Kochanek P.M., Wu X., Tisherman S.A., et al. Emergency Preservation and Resuscitation Methods: Pat. No. US8628512B2; App. №11/471,762; Pub. 03.02.2011.
  20. Dovey D. U.S. Military Wants to Freeze Soldiers in Suspended Animation in Order to Save Their Lives. Newsweek Magazine. 2018. [Internet] https://www.newsweek.com/us-military-wants-freeze-soldiers-suspended-animation-order-save-their-lives-832976 (cited 2023 Oct 1).
  21. Moffatt S.E., Mitchell S.J.B., Walke J.L. Profound Hypothermia in Haemorrhagic Shock, Friend or Foe? A Systematic Review. J. R. Army Med. Corps. 2018;164:191–196.
  22. Alam H.B., Chen Z., Honma K., et al. The rate of nduction of Hypothermic Arrest Determines the Outcome in a Swine Model of Lethal Hemorrhage. J Trauma. 2004;57;5:961–969.
  23. Alam H.B., Rhee P., Honma K., et al. Does the Rate of Rewarming from profound Hypothermic Arrest Influence the Outcome in a Swine Model of Lethal Hemorrhage?. J Trauma. 2006;60;1:134–146.
  24. Behringer W., Safar P., Wu X., et al. Survival without brain damage after clinical death of 60-120 mins in dogs using suspended animation by profound hypothermia. Brain Damage after Clinical Death of 60-120 mins in Dogs Using Suspended Animation by Profound Hypothermia. Crit. Care Med. 2003;31;5:1523–1531.

 

The material was received 04.10.23; the article after peer review procedure 10.10.23; the Editorial Board accepted the article for publication 22.12.23