Review article

Prospects of N-Acetylcysteine Use as a Nephroprotector in Patients with Concomitant Trauma and other Pharmacological Aspects of Clinical Use of this Substance

Miziev I.A. 1, Makhov M.Kh. 1, Gubzhokova A.B. 1, Kardanov A.A. 1, Kardanova L.D. 1

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1 Kabardino-Balkarian State University named after H.M. Berbekov, Nal’chik, Russian Federation

UDC 615.03:616-001

Pp. 45–50

Summary. Objectives of the study were to analyze a wide range of published data; to study biological activity and bioavailability of N-acetylcysteine (N-AC) as well as a possibility of using the drug in clinical practice to eliminate oxidative stress and inflammatory reactions in pathological conditions and nosologies; to study its therapeutic effectiveness in renal dysfunction in patients with concomitant trauma.

Study materials and methods. Materials of research: scientific publications on the specified problems. Research method: analytical.

Results of the study and their analysis. A review of domestic and foreign literature on the role of N-acetylcysteine in correction of oxidative stress and protection against free radicals is presented. The great role of N-acetylcysteine for the replenishment of the intracellular content of glutathione, the main cellular antioxidant, as well as the potential possibility of using N-acetylcysteine in clinical practice for various pathologies and diseases is investigated. Review of the results of a large number of studies leads the authors to the conclusion that this pharmacological substance is a very promising means for replenishing the intracellular content of glutathione and can be used in the treatment of a number of diseases.

Keywords: clinical use, glutathione system, N-acetylcysteine, nephroprotective therapy, oxidative stress, patients with concomitant trauma, pharmacological aspects

Conflict of interest. The authors declare no conflict of interest

For citation: Miziev I.A., Makhov M.Kh., Gubzhokova A.B., Kardanov A.A., Kardanova L.D. Prospects of N-Acetylcysteine Use as a Nephroprotector in Patients with Concomitant Trauma and other Pharmacological Aspects of Clinical Use of this Substance. Meditsina Katastrof = Disaster Medicine. 2023;2:45-50 (In Russ.). https://doi.org/10.33266/2070-1004-2023-2-45-50



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The material was received 02.03.23; the article after peer review procedure 26.04.23; the Editorial Board accepted the article for publication 23.06.23