DISASTER MEDICINE No. 3 •2026

doi: 10.33266/2070-1004-2026-3

EXPERIMENTAL RESEARCH

Original article

Application of Stem Cell-Derived Paracrine Factors to Accelerate Bone Tissue Regeneration in Experimental Study

Koptev V.Yu. 1, Bulygin Ya.I. 2, Temnov P.A. 3, Sklifas A.N. 4, Temnov A.A. 4,5

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1 Institute of Experimental Veterinary Medicine of Siberia and the Far East, Siberian Federal Scientific Center for Agrobiotechnology, Russian Academy of Sciences, Novosibirsk, Russian Federation

2 Medical University of the Russian Scientific Center of Surgery named after Acad. B.V.Petrovskiy, Moscow, Russian Federation

3 Medical Institute of the Peoples’ Friendship University of Russia named after Patrice Lumumba, Moscow, Russian Federation

4 Institute of Cell Biophysics, Federal Research Center “Pushchino Scientific Center for Biological Research, Russian Academy of Sciences”, Pushchino, Russian Federation

5 State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russian Federation

UDC 355.415.6:355.424.8:685.184

P. 109-115

 

Summary. The aim of the study was to evaluate the effectiveness of paracrine factors derived from stem cells on the dynamics of bone defect repair in laboratory animals, depending on the route of administration.

Materials and methods. The study was conducted at the Animal Diseases Laboratory of the Institute of Experimental Veterinary Medicine of Siberia and the Far East, Siberian Federal Scientific Center of Agrobiotechnology, Russian Academy of Sciences.

Research methods – modeling of bone injury, control of the wound process, cultivation of mesenchymal stem cells, obtaining conditioned medium during their cultivation.

Study results and analysis. The analysis results showed that paracrine factors secreted by stem cells may be promising for further research aimed at developing a drug.

Keywords: bone tissue regeneration, drug, laboratory animals, mesenchymal stem cells, paracrine factors

For citation: Koptev V.Yu., Bulygin Ya.I., Temnov P.A., Sklifas A.N., Temnov A.A. Application of Stem Cell-Derived Paracrine Factors to Accelerate Bone Tissue Regeneration in Experimental Study. Meditsina Katastrof = Disaster Medicine. 2026;3:109-115 (In Russ.). Doi:10.33266/2070-1004-2026-3-109-115

 

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The material was received 24.02.26; the article after peer review procedure 25.06.26; the Editorial Board accepted the article for publication 16.09.26
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