DISASTER MEDICINE No. 1 •2025

https://doi.org/10.33266/2070-1004-2025-1

IN ORDER OF DISCUSSION

Original article

Efficiency of Humic Substances in Patients with Inflammation and Pain Syndrome of the Knee Joint during Postoperative Medical Rehabilitation 

Umnikov A.S. 1, Samoylov A.S. 1, Velichko M.N. 1, Shturmin A.V. 1, Apryshko O.E. 1, Krasnobay S.V. 1, Grechukhin D.A. 1, Shurygina A.A. 1

Download the article in pdf format

1 State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russian Federation

UDC 617-089.844:611.728.3:356

Pp. 71-77

 

Summary. The aim of the study is to evaluate the effectiveness of using a drug based on an extract of humic substances to reduce the inflammatory response and the severity of pain syndrome, as well as to accelerate functional recovery in patients in the postoperative period after surgery on the knee joint.

Materials and methods of the study. The study involved 60 patients divided into study group and control groups. Patients in the study group received a drug based on humic substances in addition to standard therapy. The effect of humic substance extract on the inflammatory response, severity of pain syndrome and functional recovery of the joint in the postoperative period was studied.

Research results and their analysis. The analysis of the study results showed a significant decrease in the levels of pro-inflammatory biomarkers (CRP, IL-6 and TNF-α), a decrease in swelling and pain, and an increase in the range of motion in the knee joint in patients receiving humic substances. In addition, subjective assessment showed high patient satisfaction with this treatment and a decrease in the need for additional analgesics. The anti-inflammatory and analgesic activity of humic substances allows us to recommend them as an effective means of improving postoperative recovery and improving the quality of life of patients after knee surgery.

Keywords: humic substances, inflammation, knee joint, pain syndrome, patients, postoperative medical rehabilitation, surgical intervention 

For citation: Umnikov A.S., Samoylov A.S., Velichko M.N., Shturmin A.V., Apryshko O.E., Krasnobay S.V., Grechukhin D.A., Shurygina A.A. Efficiency of Humic Substances in Patients with Inflammation and Pain Syndrome of the Knee Joint during Postoperative Medical Rehabilitation. Meditsina Katastrof = Disaster Medicine. 2025;1:71-77 (In Russ.). https://doi.org/10.33266/2070-1004-2025-1-71-77

 

REFERENCES

  1. Stevenson F.J. Humus Chemistry: Genesis, Composition, Reactions. New York: Wiley, 1994. 496 p.
  2. Schnitzer M., Khan S.U. Humic Substances in the Environment. New York, Dekker, 1972. 327 p.
  3. Riede U.N., Kopp J., Maier K.P. Immunopharmacological and Therapeutic Aspects of Fulvic and Humic Acids in Inflammatory Diseases. Journal of Medicinal Chemistry. 1984;27;3:345-352.
  4. Pustovoyt V.I., Astrelina T.A., Balakin Ye.I., Kobzeva I.V., Stepanov A.A., Sinitsyna A.A., Izotov A.A., Butkova T.V., Belorusova A.Ye., Samoylov A.S. Evaluation of in vitro Cytotoxicity of ACVR-IN-01 Substance on a Cellular Model. Infektsionnyye Bolezni = Infectious Diseases. 2022;3;20:83-91 (In Russ.).
  5. Van Rensburg C.E.J., Dekker J. Anti-Inflammatory and Antioxidant Properties of Humic Acid. Inflammation. 2007. V.30. No.2. P. 132-138.
  6. Belcaro G., Cesarone M.R., Dugall M. Treatment of Joint Disorders with a Humic Acid-Based Compound: A Pilot Study. Clinical Interventions in Aging. 2012;7:145-151.
  7. Mikheyev S.Yu., Pustovoyt V. I., Yurku K.A., Ivanov M.V. Features of Medical and Biological Support of Athletes with Limb Amputations. Klinicheskiy Vestnik FMBTS Im. A.I. Burnazyana = Clinical Bulletin of the A.I. Burnazyan Federal Medical and Biological Center 2024;3:38-42 (In Russ.). doi: 10.33266/2782-6430-2024-3-38-4.
  8. Kulikova N.A., Stepanova E.V., Perminova I.V. Natural Humic Acids: Fundamental and Applied Aspects. A Review. Environmental Chemistry Letters. 2005;3:147-154.
  9. Ivanov M.V., Samoylov A.S., Pustovoyt V.I. Efficiency of Using Various Methods of Shock Wave Therapy in the Complex Treatment of Athletes with Lateral Epicondylitis. Sportivnaya Meditsina: Nauka i Praktika = Sports Medicine: Science and Practice. 2022;12;4:5-10 (In Russ.). doi.: 10.47529/2223-2524.2022.4.1.
  10. Mikheev S., Pustovoyt V., Yurku K. Dependence of Prolactin on The Level of Lower Limb Amputation in Paralympic Athletes. Journal of Clinical Physiology and Pathology (JISCPP). 2024;3;1:56-57. doi.: 10.59315/jiscpp.2024-3-1.56-57.
  11. Nava M.B., Tedesco D., Ventura C. Humic Substances as a Modulator of Cytokine Release in Chronic Inflammatory Diseases. European Journal of Clinical Pharmacology. 2001;56;8:605–611.
  12. Mikheyev S.Yu., Pustovoyt V.I., Mikheyeva V.M., Yurku K.A., Ivanov M.V. Amputation Level and Prolactin: Features of the Hormonal Profile of Paralympic Athletes. Klinicheskiy Vestnik FMBTS im. A.I. Burnazyana = Clinical Bulletin of the A.I. Burnazyan Federal Medical and Biological Center 2024;3:34-37 (In Russ.). doi: 10.33266/2782-6430-2024-3-34-37.

 

The material was received 31.01.25; the article after peer review procedure 04.03.25; the Editorial Board accepted the article for publication 13.03.25