DISASTER MEDICINE No. 3•2021

https://doi.org/10.33266/2070-1004-2021-3

Original article

Application of Regenerative Cell Technologies in the Treatment of Severe Local Radiation Injuries in Victims of Emergency Situations: from the Experience of the Specialists of the Federal Medical Biophysical Center Named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia

Download the article in pdf format

Astrelina T.A.1, Aksenenko A.V.1, Kobzeva I.V. 1, Brunchukov V.A.1, Usupzhanova D.Yu.1

1 State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russian Federation

UDC 60.606, 61.617-089, 61.616-08-031.84,61.616-08-039.34

Pp. 58-64

Abstract. It has been noted that one of the most common types of radiation injuries when a person is exposed to ionizing radiation is radiation burns — severe local radiation injuries.

The aim of the study is to apply stromal and vascular fraction of adipose tissue to increase the efficiency of complex therapy for local radiation lesions.

Materials and methods of the study. In 2017-2019, 7 patients (all male; mean age — (54.83±9.41) years) with local radiation lesions of the skin — ulcerative-necrotic lesions of the skin and underlying tissues — were treated at the Federal Medical Biophysical Center named after A.I. Burnazyan of FMBA of Russia. For more than 6 months the patients received conventional conservative therapy of local radiation lesions and a single injection of cell suspension of autologous cells of stromal-vascular fraction of adipose tissue — the average number of cells was (60.33×106±64.04).

Results of the study and their analysis. All patients had no serious adverse events and reactions associated with the introduction of autologous regenerative cells of adipose tissue. During the whole period of observation after stromal-vascular fraction of adipose tissue was injected, late radiation ulcers remained without signs of inflammation and infiltration. The patients were discharged from the hospital in satisfactory condition.

According to the authors, the use of stromal-vascular fraction of adipose tissue in local radiation lesions provides favorable conditions: to increase the effectiveness of complex therapy; to reduce healing time of the wound surface; to regulate and activate immune and reparative processes in the dermis; to restore the damaged vascular network, lost skin without severe scarring changes; to heal and achieve a satisfactory result, decent quality of life of patients.

Keywords: cell therapy, emergencies, radiation, regenerative cell technologies, severe local radiation injuries, stromal-vascular fraction of adipose tissue, victims

For citation: Astrelina T.A., Aksenenko A.V., Kobzeva I.V., Brunchukov V.A., Usupzhanova D.Yu.

Application of Regenerative Cell Technologies in the Treatment of Severe Local Radiation Injuries in Victims of Emergency Situations: from the Experience of the Specialists of the Federal Medical Biophysical Center Named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia. Meditsina katastrof = Disaster Medicine. 2021;3:58-64 (In Russ.). https://doi.org/10.33266/2070-1004-2021-3-58-64

 

REFERENCES

  1. Ilyin L.A., Solovyev V.Yu. Immediate Medical Consequences of Radiation Incidents on the Territory of the Former USSR. Medical Radiology and Radiation Safety. 2004;49;6:37-48 (In Russ.).
  2. Yarmonenko SP, Vainson AA. Radiobiology of Humans and Animals. Textbook. Moscow, Vys`shaya Shcola Publ., 2004. 549 p. (In Russ.).
  3. Solovyev V.Yu., Bushmanov A.Yu., Barabanova A.V. Analysis of the Medical Consequences of Radiation Incidents on the Territory of the Former USSR. Medical Radiology and Radiation Safety. 2012;57;6:36-42 (In Russ.).
  4. Okladnikova N.D., Yemanova E.A., Gus’kova A.K., et al. Consequences and Outcomes of Occupational Radiation Burns. Medical Radiology and Radiation Safety. 2003;48;2:35-41 (In Russ.).
  5. Local Radiation Injuries in the Population: Diagnosis and Treatment. Ed. Prof. Guskova A.K. Moscow, VTSMK Zashchita Publ., 2001. 76 p. (In Russ.).
  6. Donika A.D., Poroyskiy S.V. Fundamentals of Radiobiology. Study guide. Volgograd, 2010 (In Russ.).
  7. Radiation Medicine. Ed. By L.A. Ilyin. Moscow, IZDAT Publ., 2001. V.2. P.161-203 (In Russ.).
  8. Solovyev V.Yu., Bushmanov A.Yu., Barabanova A.V., Biryukov A.P., Khamidulin T.M. Analysis of the Professional Affiliation of Victims of Radiation Incidents on the Territory of the Former USSR. Medical-Biological and Social-Psychological Problems of Safety in Emergency Situations. 2011;1:5-9 (In Russ.).
  9. Vechkanov E.M., Vnukov V.V. Fundamentals of Radiation Biophysics. Tutorial. Rostov-na-Donu, JuFU Publ., 2009. 50 p. (In Russ.).
  10. Chernukha A.M., Frolov E.P. Skin (Structure, Function, General Pathology and Therapy). Moscow, Medicine Publ., 1982. 336 p. (In Russ.).
  11. Nadezhina N.M., Galstyan I.A. Treatment of Local Radiation Injuries. Ed. by Prof. Kotenko K.V. and Prof. Bushmanov A.Yu. Moscow, A.I. Burnazyan FMBC Publ., 2013. 99 p. (In Russ.).
  12. Milanov N.O., Shilov B.L. Plastic Surgery of Radiation Injuries. Moscow, AIR-ART Publ., 1996. 78 p. (In Russ.).
  13. Shilov B.L. Modern Methods of Reconstructive Plastic Surgery in the Treatment of Tissue Radiation Damage: Extended Abstract of Doctor`s Thesis in Medicine. Moscow, NTSKH RAMS Publ., 1993. 20 p. (In Russ.).
  14. Petushkov V.N., Barabanova A.V., Krylov V.M. Guidelines and Recommendations for the Diagnosis and Treatment of Acute Local and Concomitant Radiation Injury. Moscow, MEDGIZ Publ., 1978 (In Russ.).
  15. Kizhaev E.V. Clinic and Treatment of Local Radiation Injuries. Military Medical. Journal. 1993;6:57-61 (In Russ.).
  16. Guskova A.K. Local Treatment of Acute Radiation Injuries. Clinical Medicine. 1986;11:113-118 (In Russ.).
  17. Filin S.V., Sachkov A.V., Ivanova E.Yu., Protasova T.G., Selidovkin G.D. Early Surgical Treatment of Local Radiation Injuries. Meditsina Katastrof = Disaster Medicine. 2003;2:42-45 (In Russ.).
  18. Barabanova A. Treatment of Late Radiation Injury of Skin. Advances in the Bioscience. Copyright since 1996. Elsevier Science Ltd. 1994;94:241-247.
  19. Guskova A.K. Basic Principles of Treatment of Local Radiation Injuries. Clinical Medicine. 1986;11:113-119 (In Russ.).
  20. Avetisov G.M. Local Radiation Injuries in the Population: Diagnosis and Treatment: a Guide for Doctors. Moscow, VTSMK Zashchita Publ., 2001. 76 p. (In Russ.).
  21. Vasiliev V.S. Vasilyev S.A., Karpov I.A., Migranova N.V. The Role of Adipose Tissue Autotransplantation in the Treatment of Soft Tissue Radiation Injuries. Bulletin of SUSU. Series Education, Health Care, Physical Education. 2013;13;2:126-124 (In Russ.).

The material was received 19.03.21; the article after peer review procedure 12.07.21; the Editorial Board accepted the article for publication 10.09.21

 
Copyright © 2024 “Disaster Medicine” Journal | Powered by “Disaster Medicine” Journal