DISASTER MEDICINE No. 3•2021

https://doi.org/10.33266/2070-1004-2021-3

Original article

Risk of Death from Hypertension among Chernobyl Accident Liquidators – Nuclear Industry Workers

Download the article in pdf format

Tukov A.R.1, Shafranskiy I.L.1, Prokhorova O.N.1, Kalinina M.V.1

1 State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russian Federation

UDC 616.005.2

Pp. 47-51

Abstract. The aim of the study was to assess the radiation risk of death from hypertension in liquidators of the Chernobyl nuclear power plant accident consequences — workers of the nuclear industry — using doses from various types of irradiation.

Materials and methods of the study. The study was conducted using data from the Industry Register of Persons exposed to radiation as a result of the Chernobyl accident — workers of the nuclear power industry. Information on 12659 liquidators (all male) was included in the analysis. 1327 of them got occupational radiation doses. Crude relative risks of death from hypertension were estimated for five dose groups using internal controls. Based on the stratified data file, a Poisson regression procedure was performed using the AMFIT module of Epicure program and the excess relative risk of death from hypertension was calculated and the nature of the dose-dependent excess relative mortality was investigated.

Results of the study and their analysis. Direct estimates of radiogenic risk of death from hypertension were obtained. No increase in mortality from hypertensive disease per unit dose was found for both the doses received during the liquidation of the Chernobyl accident consequences and for the total doses. The results of the study can be used in the development of radiation safety regulations for persons working with sources of ionizing radiation.

Keywords: AMFIT, Chernobyl accident, EPICURE, hypertension, industry register, liquidators, nuclear industry workers, radiation, relative risk, risk of death, Rosatom State Corporation, study period

For citation: Tukov A.R., Shafranskiy I.L., Prokhorova O.N., Kalinina M.V.

Risk of Death from Hypertension among Chernobyl Accident Liquidators – Nuclear Industry Workers. Meditsina katastrof = Disaster Medicine. 2021;3:47-51 (In Russ.). https://doi.org/10.33266/2070-1004-2021-3-47-51

 

REFERENCES

  1. Dale L.P., Shimizu Y., Donald A.P., Akihiko Suyamac A., Mabuchi K. Studies of Mortality of Atomic Bomb Survivors. Report 13: Solid Cancer and Noncancer Disease Mortality: 1950–1997. Radiation Research. 2003;160:381–407.
  2. Shantyr’ I.I., Astaf’ev O.M., Makarova N.V. The Health Status of Liquidators of the Consequences of the Chernobyl Accident: Po materialam Sev.–Zap. region. centra Ros. gos. med. dozimetr. reg. Vseross. Centr Ekstr. i Radiat. Meditsiny MCHS Rossii. SPb.: Sev.–Zap. region. tsentr RGMDR Publ., 2002. 112 р. (In Russ.).
  3. Sevan’kaev A.V., Lloyd D.C., Edwards A.A., Moiseenko V.V. High Exposures to Radiation Received by Workers Inside the Chernobyl Sarcophagus. Radiat. Protect. Dosim. 1995;59:85–91 (In Russ.).
  4. Ivanov V., Maksioutov M.A., Chekin S.Y., Petrov A.V., Biryukov A.P., Kruglova Z.G., Matyash V.A., Tsyb A.F., Manton K.G., Kravchenko J.S. The Risk of Radiation-Induced Cerebrovascular Disease in Chernobyl Emergency Workers. Health Phys. 2006;90:199–207 (In Russ.).
  5. Bіliy D.O., Nastіna O.M., Gabulavіchene Zh.M., Sidorenko G.V., Bazika O.D., Bіlaya V.V., Koval’ov O.S. Factor of Radioactive and Non-Radioactive Nature and its Inflow for the Overload of Ischemic Ailments of the Heart among the Participants in the Loss of Inheritance from the Chernobyl Accident. Problemy Radіatsіonnoy Meditsiny i Radіobіologiі. 2014;19:213-222 (In Ukr.).
  6. Buzunov V.O., Prikashchikova K.Є., Gubіna І.G., Kostyuk G.V., Tereshchenko S.O. Mortality due to Ailments of the Blood Circulation System in Radioactively Disturbed Territories of Accidents at the ChAES for 1988–2010. Problemy Radіatsіonnoy Meditsiny i Radіobіologiі. 2013;18:50-58 (In Ukr.).
  7. Buzunov V.O., Prikashchikova K.Є., Kostyuk G.V., Gubіna І.G., Tereshchenko S.O. Mortality due to Ailments of the Blood Circulation System in Radioactively Disturbed Territories of Ukraine during Accidents at the ChAES is Largely due to the Doses of Radioactive Evaluation. 1988-2010 Rocky with Caution. Problemy Radіatsіonnoy Meditsiny i Radіobіologiі. 2014;19:59-66 (In Ukr.).
  8. Muirhead C.R., O’Hagan J.A., Haylock R.G.E., Phillipson M.A., Willcock T., Berridge G.L.C., Zhang W. Mortality and Cancer Incidence Following Occupational Radiation Exposure: Third Analysis of the National Registry for Radiation Workers. British Journal of Cancer. 2009;100:206–212.
  9. Krauser M., Kreisheimer M., Kandel M. Mortality from Cardio-Vascular Riseases in the German Uranium Miners Cohort Study 1946-1998. Rad Env Biophysics. 2006.
  10. Azizova T.V., Colin R., Muirhead Maria B,. Moseeva Evgenia S., Grigoryeva Margarita V., Sumina J., O’Hagan J.A., Wei Zhang R.J., Haylock G.E., Hunter N. Cerebrovascular Diseases in Nuclear Workers First Employed at the Mayak PA in 1948–1972. Radiat Environ Biophys. 2011;50:539–552.
  11. Azizova T.V., Muirhead C.R., Moseeva M.B. Ischemic Heart Disease in Nuclear Workers First Employed at the Mayak PA in 1948–1972. Health Phys. 2012;103;1:3–14.
  12. Moseeva M.B., Azizova T.V., Grigorieva E.S., Haylock R. Risk of Circulatory Diseases Among Mayak PA Workers with Radiation Doses Estimated Using the Improved Mayak Workers Dosimetry System 2008. Rad. Environ. Biophys. 2014;53;2:469–477.
  13. Little M.P., Tawn E.J., Tzoulaki I., Wakeford R., Hildebrandt G., Paris F., Tapio S., Elliotta P. A Systematic Review of Epidemiological Associations between Low and Moderate Doses of Ionizing Radiation and Late Cardiovascular Effects, and Their Possible Mechanisms. Radiation Research. 2008;169:99–109.
  14. Little M.P., Azizova T.V., Bazyka D. Systematic Review and Meta-Analysis of Circulatory Disease from Exposure to Low-level Ionizing Radiation and Estimates of Potential Population Mortality Risks. Environ. Health Perspect. 2012;120:1503–1511.
  15. Vrijheid M., Cardis E., Ashmore P., Auvinen A., Bae J-M., Engels H., Gilbert E., Gulis G., Habib R.R., Howe G., Kurtinaitis J., Malker H., Muirhead C.R., Richardson D.B., Rodriguez-Artalejo F., Rogel A., Schubauer-Berigan M., Tardy H., Telle-Lamberton M., Usel M., Veress K. Mortality from Diseases Other than Cancer Following Low Doses of Ionizing Radiation: Results from the 15-Country Study of Nuclear Industry Workers. International Journal of Epidemiology. 2007;36:1126–1135.
  16. Preston D.L., Lubin J.H., Pierce D.A., McConney M.E. Epicure, User’s Guide. HiroSoft International Corporation. Seattle, WA 98112, USA, 1993. 329 p.
  17. Metlyaeva N.A., Bushmanov A.YU., Krasnyuk V.I., Shcherbatykh O.V., Bolotnov M.V. Review of Scientific Publications on Human Response to Ionizing Radiation. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’. 2016;5:48-54 (In Russ.).
  18. Tayts M.Yu., Dudina T.V., Kandybo T.S., Elkina A.I. Early Effects of the Influence of Ionizing Radiation in Relatively Small Doses on the Neurotransmitter Systems Responsible for the Central Regulation of the Hypothalamic Pituitary Gland and Adreno-Corticoid System. Radiobiologiya. 1988;28;5:660–662 (In Russ.).
  19. Kazuo K., Shozo S. Medical X-ray Doses’ Contributions to the Ionizing Radiation Exposures of Atomic-Bomb Survivors. Journal of Radiation Research. Issue Suppl_1, 1 March 1991;32:136–153. 

The material was received 18.03.21; the article after peer review procedure 01.05.21; the Editorial Board accepted the article for publication 10.09.21