Original article

Influence of Toxic Combustion Products on the State of Intestinal Microbiota in the Pathogenesis of Nonalcoholic Fatty Liver Disease in Firefighters

Gatsura V.Y.1, Gumanenko K.E.2, Sannikov M.V.3, Kriyt V.E.4, Pyatibrat E.D.5, Pyatibrat A.O.2

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1 Occupational Health Facility, the Ministry of Internal Affairs for the City of St. Petersburg and the Leningrad region, St. Petersburg, Russian Federation

2 St. Petersburg State Pediatric Medical University, St. Petersburg, Russian Federation

3 Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, St. Petersburg, Russian Federation

4 North Western Centre for Hygiene and Public Health,St. Petersburg, Russian Federation

5 S.M.Kirov Military Medical Academy, St. Petersburg, Russian Federation

UDC 614.841:616.84:616.36

Pp. 59–65

Abstract. Medical and psychological support of professional activity of firefighters does not take into account their chronic poisoning by toxic products of burning. Such diagnoses are made to the firefighters of the State Fire Service of the Federal Fire Service of EMERCOM of Russia only in case of acute poisoning. Insufficient attention paid to the impact of fire-specific toxicants, including dioxins, does not allow timely detection of disturbances in the regulation of physiological systems of firefighters’ organisms, which leads to the emergence of diseases.

The aim of the study was to determine the effect of dioxins on the state of the microbiota.

Materials and research methods. The study involved 246 male patients, of whom 121 were employees of the State Fire Service of the Federal Fire Service of EMERCOM of Russia and 125 were civilians and rescuers of EMERCOM of Russia.

Research results and their analysis. The data obtained in the study of the blood microbiota by chromatography-mass spectrometry of microbial markers indicate a pronounced intestinal dysbiosis in firefighters with non-alcoholic fatty liver disease due to decreased number of microbial markers of the normal microbiota along with increased total number of microbial markers and opportunistic microorganisms.

The dysbacteriosis revealed in the firefighters having no health complaints can be a predictor of liver pathology development that testifies to necessity of control and timely correction of microecological status.

Keywords: dioxins, dysbiosis, firefighters, gut microbiota, nonalcoholic fatty liver disease, toxic combustion products

For citation: Gatsura V.Y., Gumanenko K.E., Sannikov M.V., Kriyt V.E., Pyatibrat E.D., Pyatibrat A.O. Influence of Toxic Combustion Products on the State of Intestinal Microbiota in the Pathogenesis of Nonalcoholic Fatty Liver Disease in Firefighters. Meditsina Katastrof = Disaster Medicine. 2022;1:59–65 (In Russ.). https://doi.org/10.33266/2070-1004-2022-1-59-65



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The material was received 04.07.21; the article after peer review procedure 17.12.21; the Editorial Board accepted the article for publication 21.03.22